Yes. Delta® two-handle kitchen, lavatory and tub/shower models can be fitted with a wide variety of handle styles to suit your tastes. Changing Delta faucet handles is simple and takes less than five minutes.
If you are changing from lever handles to knob or porcelain cross handles, you will need to re-orient the right (cold) handle stem stop so the stem stop faces inward.
If you are changing from knob or porcelain cross handles to lever handles, you will need to re-orient the right (cold) handle stem stop so the stem stop faces outward (both left and right handle stem stops should orient to the right).